Ama-pyrogens, awaziwa nangokuthi ama-endotoxins, akhiqizwa odongeni lwe-extracellular lwe-Gram-negative bacteria, okungukuthi, izingcezu zezidumbu zebhaktheriya.Kuyinto ye-lipopolysaccharide enesisindo samangqamuzana esihlobene kusukela ezinkulungwaneni ezimbalwa kuya ezinkulungwaneni ezingamakhulu amaningana, kuye ngezinhlobo zamabhaktheriya ezikhiqizayo.Emanzini, isisindo sawo samangqamuzana angahluka ukusuka kumakhulu ezinkulungwane kuye ezigidini
Uma inani elincane le-pyrogen lihlanganiswa emuthini bese lijovwa ohlelweni lwegazi lomuntu, lingabangela ukushisa okukhulu ngisho nokufa.Ngakho-ke, kuyadingeka kakhulu ukunciphisa okuqukethwe kwe-pyrogen oketshezini lokwelapha ngangokunokwenzeka, ikakhulukazi lapho umthamo (njengokumnika okukhulu) umthamo mkhulu, isidingo sokuhlushwa se-pyrogen kufanele sibe namandla kakhulu.
I-Depyrogenation yoketshezi lomjovo (noma amanzi omjovo) isixhumanisi sokukhiqiza esiyisisekelo embonini yezemithi ukuze ihlangabezane nemithetho yokuhlola ye-Pharmacopoeia.Njengamanje, izindlela ze-depyrogenation zivame ukwethula ezigabeni ezi-3 ezilandelayo:
1. Indlela ye-distillation ikhiqiza amanzi angenayo i-depyrogenated, asetshenziswa njengamanzi omjovo, amanzi okugeza, njll., kodwa izindleko zawo ziphezulu.
2. I-Depyrogenation ngendlela ye-adsorption.Enye yezindlela ukuthi i-surface adsorbent ikhangisa izinto ze-pyrogenic futhi ivumela izinto zomkhiqizo ukuthi zidlule.Indlela yesibili ukuthi i-adsorbent ikhangisa impahla yomkhiqizo futhi ivumela i-pyrogen ukuthi iphume.
3. Indlela yokuhlukanisa i-Membrane yokususwa kwe-pyrogen njengenqubo entsha kanye nobuchwepheshe obusha buyathandwa futhi busetshenziswa embonini yezokwenziwa kwemithi.Umgomo we-ultrafiltration ukuze kukhishwe i-pyrogen ukusebenzisa i-ultrafiltration membrane encane kunesisindo se-molecular ye-pyrogen ukuze ubambe i-pyrogen.Le ndlela iqinisekisiwe.Futhi inezinzuzo zokushuba kwabasebenzi abaphansi, isivuno esikhulu somkhiqizo kanye nekhwalithi enhle yomkhiqizo.
Isikhathi sokuthumela: Apr-20-2022